BALTIMORE—After Friday night’s disappointing 11-inning loss to the Philadelphia Phillies, the Orioles spotted them two runs on Saturday. But thanks to four RBIs from Anthony Santander and a strong start from Grayson Rodriguez, Baltimore came away with a 6-2 win before their third sellout crowd of the season, and the second in two games — 44,555 at Camden Yards.

Rodriguez (8-2) won his third straight, allowing two runs on seven hits, walking one and striking out six in a season-high seven innings.

Santander hit a game-tying home run in the fourth, and with the Orioles (46-24) holding a one-run lead, hit a two-run homer in the eighth. The first went 424 feet, the second 425 feet.

It was Santander’s 14^th multi-home run game and first this season. He’s hit eight homers in June and 17 for the season.

Alec Bohm’s first-inning double scored Bryce Harper, and the damage would have been worse had centterfielder Cedric Mullins not made a diving catch on Bryson Stott’s sinking liner to end the inning.

Mullins made a nearly identical play on Brandon Marsh to begin the fifth.

Edmundo Sosa hit his fifth home run leading off the second for the Phillies (47-23).

Ramón Urias doubled against Phillies starter Taijuan Walker (3-2) to lead off the third, moved to third on Gunnar Henderson’s single and scored on Adley Rutschman’s sacrifice fly to right field.

After Santander’s home run tied it at 2 in the fourth, the Orioles took a 3-2 lead in the sixth when Ryan Mountcastle led off with a single and moved to third on a hit-and-run single by Ryan O’Hearn. Santander’s sacrifice fly to center scored Mountcastle.

Henderson’s RBI single scored Austin Hays in the eighth for a 6-2 lead.

Bryan Baker retired his three batters in the eighth, and Craig Kimbrel worked the ninth in a non-save situation, striking out the side.

Note: The Orioles placed right-hander Kyle Bradish on the 15-day injured list with a right ulnar collateral ligament sprain and recalled left-hander Nick Vespi from Triple-A Norfolk.